People Behind Our Research: Dr. Lisa Cassis

From: Nov 18, 2015 | kbowman

For University of Kentucky Vice President for Research Lisa Cassis the drive to conduct meaningful research is personal. “You don’t go into it for the money, you go into it because you want to help people,” Cassis said. The longtime UK professor chose to devote her career to cardiovascular research after watching her father battle heart disease for nearly 30 years.

 He suffered his first heart attack at age 51, went through three open heart surgeries, and was able to live until age 80 by managing his diet. However, Cassis says his lipid problems kept coming back no matter what he did. 

“I wanted to know why we aren’t able to help someone like him,” she said. 

Now, with more than 26 years at UK, Cassis has made many important discoveries in cardiovascular research, including a link between obesity and health problems like high blood pressure. By studying the renin angiotensin system, which helps control blood pressure and fluid in the body, Cassis and her team were able to determine how the overproduction of fat cells contribute to high blood pressure, coronary artery disease and heart failure. 

More recently, Cassis has begun studying sex chromosomes and their contribution to the vascular disease of aneurysms. 

“Females are less likely to get aneurysms than men, and I’m trying to figure out why that is,” she said.  

Her findings over the last year suggest that the introduction of male sex chromosomes in biological females could raise the risk of aneurysm. Cassis says this work may have a broader impact than she initially thought. 

“We’ve become more aware in this country of gender and gender identity,” said Cassis. “From my perspective, as a cardiovascular researcher, the process of seeking one’s gender is taking certain types of sex hormones to promote the outcome that you would like for that gender. My concern is how that therapy will influence that person’s cardiovascular health.” 

Cassis hopes her contribution will help provide knowledge to people as they seek their own gender identity, so that they may understand different types of approaches and clinical care they may need. 

At the end of the day, Cassis just wants to improve lives by doing what she loves most. 

“I love trying to come up with a question and design an approach to tackle the question,” she said. 

About Lisa Cassis

Lisa Cassis earned a bachelor's degree in pharmacy and a Ph.D. in pharmacology from West Virginia University, followed by postdoctoral positions as an Alexander Von Humboldt Fellow in Pharmacology at Wurzburg, West Germany, and within the Department of Pharmacology at the University of Virginia. Cassis joined the faculty at UK in 1988, and is currently a faculty member within the Department of Pharmacology and Nutritional Sciences, Saha Cardiovascular Research Center, the Graduate Center for Toxicology, the Barnstable Brown Diabetes and Obesity Center, and the College of Pharmacy. 

Research within the Cassis laboratory has been continuously supported by grants from the National Institutes of Health (NIH) for more than 27 years, contributing to more than 130 scholarly publications. She has mentored many scientists, been the recipient of national and local research awards, and served for 10 years as program director of an NIH Training Grant in Nutritional Sciences. She currently serves as program director for an NIH grant that supports the Center of Biomedical Research Excellence (COBRE) focusing on obesity and cardiovascular diseases.  

As vice president for research, Cassis reports directly to the president and administers UK’s nearly $285 million research enterprise that has an annual economic impact on the state of more than $500 million. Cassis oversees research proposal development, grants and contracts administration, federal relations, human subjects protection, 10 non-degree granting and multidisciplinary research centers, and an array of shared-use core facilities that serve UK researchers. 

The University of Kentucky is one of only eight universities in the country with the full range of undergraduate, graduate, professional, and medical programs on one contiguous campus. That range of programs — world-class poets and writers working minutes away from nationally renowned researchers in cancer and energy — enlivens interdisciplinary and multidisciplinary initiatives in learning and discovery. UK is currently one of only 22 public institutions with a trifecta of federal designations of excellence — for aging, in cancer and in translational science. 

Produced by Alicia P. Gregory, videography/direction by Chad Rumford and Ben Corwin (Research Communications), text by UK Public Relations & Marketing

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